Trichophycin A, a cytotoxic linear polyketide isolated from a Trichodesmium thiebautii bloom
Bertin, Matthew J.
Wahome, Paul G.
Zimba, Paul V.
Moeller, Peter D. R.
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In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC50: 6.5 μM) and HCT-116 cells (EC50: 11.7 μM). Trichophycin A was significantly more cytotoxic than the previously isolated polyketides trichotoxin A and trichotoxin B. These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds.
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CitationBertin, M.J., Wahome, P.G., Zimba, P.V., He, H. and Moeller, P.D., 2017. Trichophycin A, a cytotoxic linear polyketide isolated from a Trichodesmium thiebautii bloom. Marine drugs, 15(1), p.10.
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