Updating and validating a currently-used gas dynamics model using parameter estimates for California sea lions (Zalophus californianus)

dc.contributor.advisorFahlman, Andreas
dc.contributor.advisorSterba-Boatwright, Blair
dc.contributor.authorHodanbosi, Matthew Robert
dc.descriptionA thesis Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER of SCIENCE in MARINE BIOLOGY from Texas A&M University-Corpus Christi in Corpus Christi, Texas.en_US
dc.description.abstractTheoretical models are used to predict how breath-hold diving vertebrates manage O2, CO2, and N2 while underwater. One recent gas dynamics model used available lung and tracheal compliance data from various species to predict O2, CO2, and N2¬ tensions in multiple tissues of diving marine mammals. As variation in respiratory compliance significantly affects alveolar compression and pulmonary shunt, the objective of this thesis was to evaluate changes in model output when using species-specific parameters from California sea lions (Zalophus californianus). I explored the effects of lung and dead space compliance on the uptake of N2, O2, and CO2 in various tissues during a series of hypothetical dives. The updated parameters allowed for increased compliance of the lungs and an increased stiffness in the trachea. When comparing updated model output with a model using previous compliance values, there was a large decrease in N2 uptake but little change in O2 and CO2 levels. Therefore, previous models may overestimate N2 tensions and the risk of gas-related disease, such as decompression sickness (DCS), in marine mammals. Using recently-collected empirical arterial and venous PO2 data, I was able to test the model output against species-specific data for the first time. This showed that lung collapse can be altered by changing physiological parameters and that model input parameters may need to vary between dives. The results of this study suggest that previous models using data that is not species-specific may inaccurately predict the risk of gas-related disease in marine mammals. Future research can use physiological parameters from other marine mammal species as they become available to best estimate the risk of DCS in those species.en_US
dc.description.collegeCollege of Science and Engineeringen_US
dc.description.departmentLife Sciencesen_US
dc.rightsThis material is made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. The user assumes full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used should be fully credited with its source. All rights are reserved and retained regardless of current or future development or laws that may apply to fair use standards. Permission for publication of this material, in part or in full, must be secured with the author and/or publisher.en_US
dc.subjectcomparative physiologyen_US
dc.subjectgas dynamicsen_US
dc.subjectmarine mammalsen_US
dc.subjectmathematical modelingen_US
dc.subjectphysiological modelingen_US
dc.titleUpdating and validating a currently-used gas dynamics model using parameter estimates for California sea lions (Zalophus californianus)en_US
thesis.degree.disciplineMarine Biologyen_US
thesis.degree.grantorTexas A & M University--Corpus Christien_US
thesis.degree.nameMaster of Scienceen_US


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