Belisle, Richard SVia, Christopher W.Schock, Tracey BVillareal, Tracy AZimba, Paul V.Beauchesne, Kevin RMoeller, Peter D RBertin, Matthew J.2022-03-242022-03-242017-09-17Belisle, R.S., Via, C.W., Schock, T.B., Villareal, T.A., Zimba, P.V., Beauchesne, K.R., Moeller, P.D. and Bertin, M.J., 2017. Trichothiazole A, a dichlorinated polyketide containing an embedded thiazole isolated from Trichodesmium blooms. Tetrahedron letters, 58(43), pp.4066-4068.https://hdl.handle.net/1969.6/90316Mass spectrometry-guided isolation of the lipophilic extract of Trichodesmium bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (1). The structure of 1 was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4-disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2A cells (EC50: 13.3 ± 1.1 μM).en-UStrichodesmiumheterocyclesthiazoleArticlehttps://doi.org/10.1016/j.tetlet.2017.09.027