The Impact of a Large Bolus Dose of L-leucine and L-isoleucine on Enteroendocrine and Pancreatic Hormones, and Glycemia in Healthy, Inactive Adults.

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dc.contributor.authorNewmire, Daniel E.
dc.contributor.authorRivas, Eric
dc.contributor.authorDeemer, Sarah E.
dc.contributor.authorWilloughby, Darryn S.
dc.contributor.authorBen-Ezra, Victor
dc.date.accessioned2019-11-08T18:31:24Z
dc.date.available2019-11-08T18:31:24Z
dc.date.issued2019-11-04T00:00-06:00
dc.description.abstractBackground: The ingestion of whey protein and amino acids with carbohydrate (CHO) enhances the release of glucagon-like peptide-1 (GLP-1) and glucose-dependent-insulinotropic peptide (GIP) that promote insulin secretion. It is unknown if L-isoleucine (Ile) and L-leucine (Leu) have this same effect. The purpose of this study was to examine how Ile and Leu influence both GLP-1 and GIP, subsequent pancreatic hormones, and glycemia in healthy, inactive adults. Methods: Twelve adults (6F/6M; age 27.4 ± 2 years; BMI 26.3 ± 2 kg/m2; lean body mass 53.2 ± 5 kg; body fat 34.1 ± 3%) completed four conditions in a randomized, cross-over fashion. Treatments standardized (0.3 g/kg·LBM−1) (1) Leu, (2) Ile, (3) Equal (1:1 g) of Leu + Ile, and (4) placebo (Pla, 3.5 g inert stevia) ingested 30 min prior to an oral glucose tolerance test (OGTT). Samples of plasma glucose, insulin, glucagon, GIPTotal, and GLP-1Active were assessed. Results: A treatment (p = 0.01) effect comparing Ile vs. Leu (p = 0.02) in GIPTotal. Area under the curve showed an increase in GIPTotal from Ile compared to Leu and Pla (p = 0.03). No effect was found on GLP-1. The ingestion of Ile prior to CHO augmented GIP concentration greater than Leu or Pla. No correlation was found between GIP, insulin, and glucose between conditions. Conclusions: Ile impacts GIP concentration, which did not relate to either insulin or glucose concentrations. Neither Ile, nor Leu seem to have an effect on hyperglycemia ingested prior to a CHO drink.en_US
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/1969.6/87374
dc.language.isoenen_US
dc.publisherJournal of Nutrients, MDPIen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectL-isoleucineen_US
dc.subjectL-leucineen_US
dc.subjectglucagon-like peptide 1en_US
dc.subjectglucose-dependent insulinotropic peptideen_US
dc.subjectglycemiaen_US
dc.titleThe Impact of a Large Bolus Dose of L-leucine and L-isoleucine on Enteroendocrine and Pancreatic Hormones, and Glycemia in Healthy, Inactive Adults.en_US
dc.typeArticleen_US

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