Obesity-related oxidative stress: The impact of physical activity and diet manipulation

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dc.contributor.authorHuang, Chun-Jung
dc.contributor.authorMcAllister, Matthew J.
dc.contributor.authorSlusher, Aaron
dc.contributor.authorWebb, Heather E.
dc.contributor.authorMock, Thomas
dc.contributor.authorAcevedo, Edmund
dc.creator.orcidhttp://orcid.org/0000-0002-0425-8311en_US
dc.creator.orcidhttps://orcid.org/0000-0002-0695-8178en_US
dc.creator.orcidhttp://orcid.org/0000-0002-3925-9613en_US
dc.creator.orcidhttp://orcid.org/0000-0001-9604-0362en_US
dc.creator.orcidhttp://orcid.org/0000-0002-6616-9234en_US
dc.creator.orcidhttps://orcid.org/0000-0002-0425-8311
dc.creator.orcidhttps://orcid.org/0000-0002-0695-8178
dc.creator.orcidhttps://orcid.org/0000-0002-3925-9613
dc.creator.orcidhttps://orcid.org/0000-0001-9604-0362
dc.creator.orcidhttps://orcid.org/0000-0002-6616-9234
dc.creator.orcidhttps://orcid.org/0000-0002-0425-8311
dc.creator.orcidhttps://orcid.org/0000-0002-0695-8178
dc.creator.orcidhttps://orcid.org/0000-0002-3925-9613
dc.creator.orcidhttps://orcid.org/0000-0001-9604-0362
dc.creator.orcidhttps://orcid.org/0000-0002-6616-9234
dc.date.accessioned2022-03-21T18:48:07Z
dc.date.available2022-03-21T18:48:07Z
dc.date.issued2015-09-23
dc.description.abstractObesity-related oxidative stress, the imbalance between pro-oxidants and antioxidants (e.g., nitric oxide), has been linked to metabolic and cardiovascular disease, including endothelial dysfunction and atherosclerosis. Reactive oxygen species (ROS) are essential for physiological functions including gene expression, cellular growth, infection defense, and modulating endothelial function. However, elevated ROS and/or diminished antioxidant capacity leading to oxidative stress can lead to dysfunction. Physical activity also results in an acute state of oxidative stress. However, it is likely that chronic physical activity provides a stimulus for favorable oxidative adaptations and enhanced physiological performance and physical health, although distinct responses between aerobic and anaerobic activities warrant further investigation. Studies support the benefits of dietary modification as well as exercise interventions in alleviating oxidative stress susceptibility. Since obese individuals tend to demonstrate elevated markers of oxidative stress, the implications for this population are significant. Therefore, in this review our aim is to discuss (i) the role of oxidative stress and inflammation as associated with obesity-related diseases, (ii) the potential concerns and benefits of exercise-mediated oxidative stress, and (iii) the advantageous role of dietary modification, including acute or chronic caloric restriction and vitamin D supplementation.en_US
dc.identifier.citationHuang, C.J., McAllister, M.J., Slusher, A.L., Webb, H.E., Mock, J.T. and Acevedo, E.O., 2015. Obesity-related oxidative stress: the impact of physical activity and diet manipulation. Sports medicine-open, 1(1), pp.1-12.en_US
dc.identifier.doihttps://doi.org/10.1186/s40798-015-0031-y
dc.identifier.urihttps://hdl.handle.net/1969.6/90284
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOxidative Stressen_US
dc.subjectNitric Oxideen_US
dc.subjectResveratrolen_US
dc.subjectCaloric Restrictionen_US
dc.subjectAerobic Exerciseen_US
dc.titleObesity-related oxidative stress: The impact of physical activity and diet manipulationen_US
dc.typeArticleen_US

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