Synthesis and characterization of aspartic acid-based tripeptide surfactants

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dc.contributor.advisorBilliot, Eugene J.
dc.contributor.advisorBilliot, Fereshteh H.
dc.contributor.authorSwonke, Roslyn Camille
dc.contributor.committeeMemberAzad, Chandra
dc.contributor.committeeMemberOlson, Mark A
dc.creator.orcidhttps://orcid.org/0009-0000-7592-672X
dc.date.accessioned2024-08-09T21:53:24Z
dc.date.available2024-08-09T21:53:24Z
dc.date.issued2024-05-03
dc.description.abstractAmino acid-based surfactants (AABSs) provide a more environmentally friendly option than traditional surfactants. The introduction of amino acids into the polar headgroup increases bioavailability and biodegradation. This study aimed to introduce three amino acids at the polar headgroup to form a tripeptide surfactant. However, this study used aspartic acid (Asp) as a central amino acid at the polar headgroup and utilized its dicarboxyl groups to form peptide bonds with auxiliary amino acids, thus forming bifurcated tripeptide surfactants. This study used stoichiometric coupling with diisopropylcarbodiimide (DIC) and n-hydroxysuccinimide (NHS) to aid in synthesis. Products were examined with proton NMR (1H-NMR) to analyze synthesis results. Then, solubility tests were performed to determine relative solubility and preliminary critical micelle concentration (CMC) studies were conducted. The 1H-NMR results revealed that the current method of bifurcated tripeptide surfactant synthesis should be amended to obtain desired products, as a mixture of bifurcated tripeptide surfactants and linear dipeptide surfactants formed. Solubility tests revealed the products formed organogels, while preliminary CMC tests revealed an estimated CMC of 51.20 mM.
dc.description.collegeCollege of Science
dc.description.departmentPhysical and Environmental Sciences
dc.format.extent101 pages
dc.identifier.urihttps://hdl.handle.net/1969.6/98128
dc.language.isoen_US
dc.rightsThis material is made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. The user assumes full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used should be fully credited with its source. All rights are reserved and retained regardless of current or future development or laws that may apply to fair use standards. Permission for publication of this material, in part or in full, must be secured with the author and/or publisher.
dc.subjectamino acid based surfactant
dc.subjectamino acids
dc.subjectgreen surfactants
dc.subjectnuclear magnetic resonance
dc.subjectpeptide synthesis
dc.subjectsupramolecular chemistry
dc.subject.lcshchemistry
dc.subject.lcshorganic chemistry
dc.subject.lcshnanoscience
dc.titleSynthesis and characterization of aspartic acid-based tripeptide surfactants
dc.typeText
dc.type.genreThesis
thesis.degree.disciplineEnvironmental Science
thesis.degree.grantorTexas A & M University--Corpus Christi
thesis.degree.levelMasters
thesis.degree.nameMaster of Science

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