Blunted nocturnal salivary melatonin secretion profiles in military-related posttraumatic stress disorder

Simple item page
dc.contributor.authorPaul, Michel A.
dc.contributor.authorLove, Ryan
dc.contributor.authorJetly, Rakesh
dc.contributor.authorRichardson, Donald
dc.contributor.authorLanius, Ruth A.
dc.contributor.authorMiller, James
dc.contributor.authorMacDonald, Michael
dc.contributor.authorRhind, Shawn
dc.creator.orcidhttp://orcid.org/0000-0001-7757-8028en_US
dc.creator.orcidhttp://orcid.org/0000-0001-6610-9365en_US
dc.creator.orcidhttps://orcid.org/0000-0002-6844-9555en_US
dc.creator.orcidhttp://orcid.org/0000-0002-3897-8376en_US
dc.creator.orcidhttp://orcid.org/0000-0003-2300-0620en_US
dc.creator.orcidhttps://orcid.org/0000-0001-7757-8028
dc.creator.orcidhttps://orcid.org/0000-0001-6610-9365
dc.creator.orcidhttps://orcid.org/0000-0002-6844-9555
dc.creator.orcidhttps://orcid.org/0000-0002-3897-8376
dc.creator.orcidhttps://orcid.org/0000-0003-2300-0620
dc.creator.orcidhttps://orcid.org/0000-0001-7757-8028
dc.creator.orcidhttps://orcid.org/0000-0001-6610-9365
dc.creator.orcidhttps://orcid.org/0000-0002-6844-9555
dc.creator.orcidhttps://orcid.org/0000-0002-3897-8376
dc.creator.orcidhttps://orcid.org/0000-0003-2300-0620http://orcid.org/0000-0001-7757-8028
dc.creator.orcidhttp://orcid.org/0000-0001-6610-9365
dc.creator.orcidhttps://orcid.org/0000-0002-6844-9555
dc.creator.orcidhttp://orcid.org/0000-0002-3897-8376
dc.creator.orcidhttp://orcid.org/0000-0003-2300-0620
dc.date.accessioned2022-03-21T20:43:34Z
dc.date.available2022-03-21T20:43:34Z
dc.date.issued2019-12-09
dc.description.abstractBackground: Sleep disturbances are a hallmark of posttraumatic stress disorder (PTSD), yet few studies have evaluated the role of dysregulated endogenous melatonin secretion in this condition. Methods: This study compared the sleep quality and nocturnal salivary melatonin profiles of Canadian Armed Forces (CAF) personnel diagnosed with PTSD, using the Clinician Administered PTSD Scale (CAPS score ≥50), with two healthy CAF control groups; comprising, a “light control” (LC) group with standardized evening light exposure and “normal control” (NC) group without light restriction. Participants were monitored for 1-week using wrist actigraphy to assess sleep quality, and 24-h salivary melatonin levels were measured (every 2h) by immunoassay on the penultimate day in a dim-light (< 5 lux) laboratory environment. Results: A repeated measures design showed that mean nocturnal melatonin concentrations for LC were higher than both NC (p = .03) and PTSD (p = .003) with no difference between PTSD and NC. Relative to PTSD, NC had significantly higher melatonin levels over a 4-h period (01 to 05 h), whereas the LC group had higher melatonin levels over an 8-h period (23 to 07 h). Actigraphic sleep quality parameters were not different between healthy controls and PTSD patients, likely due to the use of prescription sleep medications in the PTSD group. Conclusions: These results indicate that PTSD is associated with blunted nocturnal melatonin secretion, which is consistent with previous findings showing lower melatonin after exposure to trauma and suggestive of severe chronodisruption. Future studies targeting the melatonergic system for therapeutic intervention may be beneficial for treatment-resistant PTSD.en_US
dc.identifier.citationPaul, M.A., Love, R.J., Jetly, R., Richardson, J.D., Lanius, R.A., Miller, J.C., MacDonald, M. and Rhind, S.G., 2019. Blunted nocturnal salivary melatonin secretion profiles in military-related posttraumatic stress disorder. Frontiers in psychiatry, p.882.en_US
dc.identifier.doihttps://doi.org/10.3389/fpsyt.2019.00882
dc.identifier.urihttps://hdl.handle.net/1969.6/90292
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectsleep disturbanceen_US
dc.subjectmelatoninen_US
dc.subjectpost-traumatic stress disorderen_US
dc.subjectdim light melatonin onseten_US
dc.subjectcircadianen_US
dc.subjectsalivaen_US
dc.titleBlunted nocturnal salivary melatonin secretion profiles in military-related posttraumatic stress disorderen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Paul_Michel_FrontiersInPsychiatry.pdf
Size:
874.06 KB
Format:
Adobe Portable Document Format
Description:
Article
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

COS Faculty Works