MariClus: Your one-stop platform for information on marine natural products, their gene clusters and producing organisms

Hermans, Cedric
Lieven De Mol, Maarten
Mispelaere, Marieke
De Rop, Anne-Sofie
Rombaut, Jeltien
Nusayr, Tesneem
Creamer, Rebecca
De Maeseneire, Sofie L.
Soetaert, Wim K.
Hulpiau, Paco
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Background: The marine environment hosts the vast majority of living species and marine microbes that produce natural products with great potential in providing lead compounds for drug development. With over 70% of Earth’s surface covered in water and the high interaction rate associated with liquid environments, this has resulted in many marine natural product discoveries. Our improved understanding of the biosynthesis of these molecules, encoded by gene clusters, along with increased genomic information will aid us in uncovering even more novel compounds. Results: We introduce MariClus (, an online user-friendly platform for mining and visualizing marine gene clusters. The first version contains information on clusters and the predicted molecules for over 500 marine-related prokaryotes. The user-friendly interface allows scientists to easily search by species, cluster type or molecule and visualize the information in table format or graphical representation. Conclusions: This new online portal simplifies the exploration and comparison of gene clusters in marine species for scientists and assists in characterizing the bioactive molecules they produce. MariClus integrates data from public sources, like GenBank, MIBiG and PubChem, with genome mining results from antiSMASH. This allows users to access and analyze various aspects of marine natural product biosynthesis and diversity.

MariClus database, marine prokaryotes, genome mining, gene clusters, natural product discovery
This research was funded by the Research Foundation Flanders (FWO), grant number S001422N, and by a PWO grant with acronym MetaTec, provided by Howest University College and the Flemish Government.
Attribution 4.0 International
Hermans, C.; De Mol, M.L.; Mispelaere, M.; De Rop, A.-S.; Rombaut, J.; Nusayr, T.; Creamer, R.; De Maeseneire, S.L.; Soetaert, W.K.; Hulpiau, P. MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms. Mar. Drugs 2023, 21, 449. https://